人類Ｔ淋巴細(xì)胞白血病病毒（HTLV-1）是導(dǎo)致人類淋巴細(xì)胞白血病、慢性脊髓癱瘓等慢性疾病的主要原因之一。Tax是HTLV-1編碼的轉(zhuǎn)錄因子，盡管它不能直接結(jié)合到病毒基因的啟動(dòng)子即 5′長(zhǎng)末端重復(fù)序列（LTR）上，但它的轉(zhuǎn)錄激活活性對(duì)于病毒復(fù)制是必需的。研究表明，宿主細(xì)胞的CREB可以與病毒基因組LTR上21bp的CRE樣序列結(jié)合。CRE樣的序列有3個(gè)，分別命名為結(jié)構(gòu)域A、B、C。CREB結(jié)合于其中的結(jié)構(gòu)域Ｂ。Tax可以通過相互作用與CBP（CREB binding protein）結(jié)合，并通過CBP將其攜帶到病毒基因組的啟動(dòng)子上。CREB-CBP-Tax復(fù)合物一旦形成，并結(jié)合到病毒基因啟動(dòng)子上，病毒基因便被激活開始轉(zhuǎn)錄和復(fù)制。HTLV-1 Tax蛋白與NF-κB活性調(diào)控蛋白相互作用表明HTLV-1 Tax蛋白通過促進(jìn)HMGB1mRNA和蛋白的表達(dá)，進(jìn)而激活NF-κB活性。

HTLV-1 causes two distinct human diseases, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T cell leukemia/lymphoma(ATL). The glycoproteins encoded by the env gene of HTLV-1 are essential for interaction with an unidentified receptor on the surface of target cells and play a crucial role in the infection process. Encoded by HTLV-1 Tax is a phospho-oncoprotein that functions as a transcriptional activator. Tax has the ability to modulate the expression and function of many cellular genes and has been crucial to understanding the HTLV-1-mediated transformation of cells. In activating cellular gene expression, Tax impinges upon several cellular signal-transduction pathways, including the CREB/ATF and NFκB pathways. In addition, Tax deregulates the expression of downstream genes, which mediate cell cycle control. The Tax protein of HTLV1 is an autoregulator of enhanced viral RNA transcription and it trans activates the viral 21 bp enhancer.

我公司新研發(fā)的磷酸化p-HTLV 1 Tax (Ser288)抗體已經(jīng)通過檢驗(yàn)測(cè)試，可以應(yīng)用于蛋白印跡（WB），免疫組化（IHC），免疫細(xì)胞化學(xué)（ICC），酶聯(lián)免疫吸附試驗(yàn)（ELISA），免疫沉淀（IP），免疫熒光（IF）實(shí)驗(yàn)。具體信息如下：

編號(hào)           產(chǎn)品名稱

PR-1027P，   p-HTLV 1 Tax (Ser288)  antibody

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鎮(zhèn)江厚普生物科技有限公司銷售部

2013-07-10